AOD-9604: TARGETED FAT LOSS

OVERVIEW:

• AOD-9604 is a synthetic peptide fragment derived from amino acids 176-191 of human growth hormone (hGH) 

• Harbors the fat reducing activity of hGH, without its negative effects 

• Does NOT increase IGF-1 or cause growth-related side effects

WHAT DOES AOD-9604 DO?

• Stimulates lipolysis (fat breakdown) in adipose tissue 

• Inhibits lipogenesis (fat formation and storage) 

• Promotes fat oxidation and metabolic efficiency 

• Supports joint health and cartilage repair

USES:

• Targeted fat loss (abdomen, hips, thighs) 

• Body composition improvement 

• Stubborn fat reduction 

• Joint health support 

• Metabolic optimization

AOD-9604 RESEARCH

Fat Loss Efficacy: Successfully completed Phase 2b human trial which proved that the drug induces weight loss and is very well tolerated with no evidence of the side effects commonly experienced with existing obesity drugs. Both human GH and AOD9604 are capable of inducing weight loss and increasing lipolytic sensitivity following long-term treatment in mice.

Safety Profile: Safety data obtained in clinical trials show it is well-tolerated with minimal side effects and multiple non-clinical studies revealed no evidence of genotoxicological or toxicological concerns regarding the safety of AOD9604.

No Growth Effects: AOD-9604 doesn't raise IGF-1 levels, doesn't stimulate insulin release, and doesn't lead to unwanted muscle growth, water retention, or bone thickening, making it a safer alternative to full growth hormone.

Joint Support: In addition to fat loss, AOD-9604 has shown potential benefits for cartilage repair and joint health, making it useful for individuals with joint concerns.

Realistic Expectations: Early studies showed some reductions in body fat mass, but findings are not consistent across trials, suggesting its fat-burning effects may be modest without lifestyle modifications including proper diet and exercise.

Potential Mechanism of Action: The exact mechanisms through which AOD-9604 exerts its effects include:

1. Mimics the lipolytic region of growth hormone

2. Activates beta-adrenergic receptors on fat cells

3. Increases breakdown of stored triglycerides into free fatty acids

4. Inhibits formation of new fat cells and storage

5. Enhances cellular energy production through fat oxidation

AOD-9604 LIFESTYLE SUPPORT

LIFESTYLE SUPPORT: 

• Caloric deficit required for optimal results 

• High-quality protein intake (1-1.2g per lb bodyweight) 

• Regular resistance training to preserve muscle mass 

• Cardiovascular exercise for enhanced fat burning 

• Adequate hydration (1 gallon+ daily)

WHAT TO EXPECT:

IMPORTANT: AOD-9604 enhances fat loss but requires proper diet and exercise!

• Fat loss enhancement is subtle and requires lifestyle adherence 

• Results typically appear within 3-6 weeks of consistent use 

• Preferential loss in stubborn fat areas (abdomen, hips, thighs) 

• Most effective when combined with caloric deficit and exercise 

• Effects are modest but consistent with proper compliance

AOD-9604 DOSING + CYCLING

Starting dose: 300mcg daily (fasted state)

AOD-9604	Bacteriostatic water added	Strength mg/mL	Dose	Frequency	Supply
10 mg Vial	10 mL	1mg/mL	300mcg (30 units)	Daily, fasted	33 days

Cycling: 8-12 weeks on, 4-6 weeks off, repeat as needed

• Administer in fasted state (morning preferred) 

• Inject 30-60 minutes before first meal 

• Can split dose: 150mcg morning + 150mcg pre-workout 

• Rotate injection sites to prevent irritation

AOD-9604 DOSING + CYCLING

Higher dose: 500mcg daily (experienced users)

AOD-9604	Bacteriostatic water added	Strength mg/mL	Dose	Frequency	Supply
10 mg Vial	6 mL	1.67mg/mL	500mcg (30 units)	Daily, fasted	20 days

Cycling: 6-8 weeks on, 4 weeks off, repeat as needed

• Higher doses show diminishing returns 

• 300mcg typically optimal for most individuals 

• Monitor for effectiveness and adjust accordingly

AOD-9604: SCREENING

AOD-9604 is generally very well-tolerated with minimal contraindications.

Screening Questions: 

• Do you have any known tumor, cancer or history of having cancer? 

• Are you pregnant or breastfeeding? 

• Do you have severe kidney or liver disease?

Reasons: • While AOD-9604 doesn't stimulate growth like full hGH, caution advised with cancer history • Insufficient safety data during pregnancy/breastfeeding • General peptide precaution for organ dysfunction

Note: AOD-9604 has an excellent safety profile with most side effects being mild and transient (injection site irritation, occasional headache). It does not affect insulin sensitivity, glucose tolerance, or other metabolic parameters unlike full growth hormone.

⚠️ Important Disclaimer

For Research Use Only: Please remember that peptides discussed here are intended for research purposes only and are not approved for human consumption.

Medical Guidance Matters: Always involve a qualified healthcare professional when exploring or learning about research peptides. Their insight helps ensure that safety comes first.

Ongoing Research is Key: Because long-term effects are still being studied, it’s important to stay curious and informed. Continued research helps you understand what may—or may not—be right for your individual goals and needs.

Quality and Sourcing: Peptide quality can vary, so take time to research reputable sources and review independent testing or third-party data whenever possible.

Know the Laws: Rules and regulations around peptides can differ depending on where you live, so be sure to check local guidelines before making any purchases.

A Final Note

This post is meant to educate and empower your own research journey. Everyone’s body and goals are unique—what works for one person may not for another. Keep learning, stay safe, and make informed choices guided by trusted medical advice.