GLUTATHIONE: MASTER ANTIOXIDANT AND DETOXIFICATION

OVERVIEW:

• Glutathione is a tripeptide composed of three amino acids: glutamine, cysteine, and glycine 

• Known as the body's "master antioxidant" and most important intracellular antioxidant 

• Naturally produced in cells but declines with age, stress, and toxin exposure

WHAT DOES GLUTATHIONE DO?

• Provides powerful antioxidant protection against free radicals 

• Supports detoxification of heavy metals and environmental toxins 

• Enhances immune system function and cellular health 

• Promotes skin brightening and anti-aging effects 

• Supports liver health and metabolic function 

• Reduces oxidative stress and inflammation

USES:

• Anti-aging and longevity optimization 

• Detoxification and liver support • Immune system enhancement 

• Skin brightening and hyperpigmentation reduction 

• Athletic recovery and performance 

• Neurological protection and brain health 

• Support during illness or toxic exposure 

• Mitochondrial health and energy production

GLUTATHIONE RESEARCH

Master Antioxidant Function: Glutathione is the most abundant antioxidant in the body and plays a crucial role in neutralizing free radicals, reducing oxidative stress, and protecting cells from damage. It recycles other antioxidants like vitamins C and E, amplifying their effectiveness.

Detoxification Support: Glutathione is essential for Phase II liver detoxification, binding to toxins, heavy metals, and metabolic waste products to facilitate their elimination from the body. It's particularly important for neutralizing environmental pollutants and xenobiotics.

Immune System Enhancement: Glutathione supports optimal immune function by protecting immune cells from oxidative damage and supporting lymphocyte proliferation. Low glutathione levels are associated with compromised immune response and increased infection susceptibility.

Age-Related Decline: Glutathione levels naturally decline with age, contributing to increased oxidative stress, reduced detoxification capacity, and accelerated aging. Supplementation may help restore youthful glutathione levels and cellular function.

Skin Brightening Effects: Glutathione inhibits tyrosinase, the enzyme responsible for melanin production, leading to skin brightening effects. It's widely used in Asia and gaining popularity worldwide for addressing hyperpigmentation and achieving more even skin tone.

Neurological Protection: Glutathione protects brain cells from oxidative damage and supports neurological health. Deficiency is associated with neurodegenerative diseases including Parkinson's, Alzheimer's, and multiple sclerosis.

Potential Mechanism of Action: Glutathione works through multiple pathways:

1. Neutralizes reactive oxygen species (ROS) and free radicals

2. Conjugates with toxins in liver for elimination

3. Recycles and regenerates other antioxidants (vitamins C, E)

4. Supports mitochondrial function and energy production

5. Modulates immune cell function and cytokine production

6. Inhibits melanin synthesis for skin brightening

7. Protects cellular DNA, proteins, and lipids from oxidative damage

GLUTATHIONE LIFESTYLE SUPPORT

LIFESTYLE SUPPORT: 

• Sulfur-rich foods: garlic, onions, cruciferous vegetables 

• Whey protein to provide cysteine for glutathione synthesis 

• Selenium and zinc for glutathione enzyme function 

• Limit alcohol consumption (depletes glutathione) 

• Regular exercise (increases glutathione production) 

• Quality sleep (7-9 hours) for cellular repair 

• Reduce toxin exposure (smoking, pollution, chemicals)

WHAT TO EXPECT:

IMPORTANT: Effects vary based on administration method and baseline status!

• Enhanced energy and reduced fatigue within days to weeks 

• Improved skin brightness and tone (2-4 weeks) 

• Better recovery from exercise and illness 

• Enhanced mental clarity and focus 

• Reduced oxidative stress markers 

• Long-term cellular protection and anti-aging benefits 

• Individual responses vary based on glutathione deficiency level

GLUTATHIONE DOSING + CYCLING

Injectable Glutathione Protocol (Most Effective):

Glutathione	BAC water added	Strength mg/mL	Dose	Frequency	Supply
1000 mg Vial	10 mL	100mg/mL	200-400mg	2-3x weekly	2.5-5 injections

Cycling: Continuous use typical for maintenance, or 8-12 weeks intensive, 2-4 weeks off

• Intramuscular or subcutaneous injection • 2-3x weekly for general health and anti-aging • Can increase frequency for intensive protocols • Rotate injection sites to prevent irritation

GLUTATHIONE DOSING + CYCLING

IV Infusion Protocol (Clinical Setting - Most Bioavailable):

Glutathione	Saline/Fluid	Dose Range	Frequency	Duration
Glutathione	50-250mL	600-2000mg	1-3x weekly	15-30 minutes

Cycling: Weekly or bi-weekly infusions for maintenance or intensive detox protocols

• Must be administered in clinical setting • Rapid infusion over 15-30 minutes (unlike NAD+) • Higher doses for intensive detoxification • Most effective delivery method for immediate effects • Popular "push" method: 1200-2000mg rapid IV

ALTERNATIVE DELIVERY METHODS:

Oral Liposomal Glutathione: • 500-1000mg daily • Best absorbed oral form (liposomal encapsulation) • Take on empty stomach for optimal absorption • Less effective than injectable but convenient  Apex Energetics Trizomal Glutathione

Oral Reduced Glutathione: • 500-1000mg daily • Poor bioavailability (significant breakdown in GI tract) • Requires consistent high doses • Most economical but least effective

Sublingual Glutathione: • 100-500mg daily • Better absorption than standard oral • Dissolve under tongue for 60-90 seconds • Moderate effectiveness

Topical/Nebulized Glutathione: • Specialized applications for specific conditions • Nebulized for respiratory conditions • Topical for localized skin benefits • Limited systemic absorption

GLUTATHIONE: SCREENING

Glutathione is generally very safe with minimal contraindications.

Screening Questions: 

• Are you pregnant or breastfeeding? 

• Do you have asthma or respiratory conditions? 

• Are you allergic to sulfur compounds? 

• Are you taking chemotherapy or immunosuppressive drugs?

Reasons: • Safety during pregnancy/breastfeeding not extensively studied • Nebulized glutathione may trigger asthma symptoms in sensitive individuals • Sulfur sensitivity may cause reactions • May interfere with certain cancer treatments (consult oncologist)

Note: Glutathione is extremely well-tolerated with very few side effects. Some individuals may experience mild nausea with IV administration or temporary lightheadedness. Injectable glutathione may cause slight discomfort at injection site. The master antioxidant effect makes it one of the safest and most beneficial supplements for overall health and longevity.