SELANK: ANXIETY RELIEF AND COGNITIVE ENHANCEMENT

OVERVIEW:

• Selank is a synthetic heptapeptide (7 amino acids) derived from tuftsin, a naturally occurring immunomodulatory peptide 

• Developed by the Institute of Molecular Genetics, Russian Academy of Sciences 

• Has anxiolytic effects comparable to benzodiazepines without sedation, dependence, or cognitive impairment

WHAT DOES SELANK DO?

• Reduces anxiety and stress without sedation

• Enhances cognitive function, memory, and learning 

• Improves mood and emotional regulation 

• Supports immune system function 

• Increases BDNF (brain-derived neurotrophic factor) 

• Provides neuroprotection and stress resilience

USES:

• Generalized anxiety disorder and stress management 

• Cognitive enhancement and focus improvement 

• Mood regulation and emotional balance 

• Memory improvement and learning optimization 

• Immune system support 

• Neuroprotection and brain health 

• Performance anxiety and stress resilience

SELANK RESEARCH

Anxiolytic Effects: The anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs, but without the associated risks of tolerance, dependence, or cognitive impairment. Clinical studies showed 40% of patients were rapid responders with symptom reduction in 1-3 days, while 60% responded gradually with significant improvements by day 14.

GABAergic Modulation: Selank affects GABA binding as a positive allosteric modulator, influencing specific binding of GABA to GABAA receptors. This mechanism is similar to benzodiazepines but without their negative side effects.

Cognitive Enhancement: Selank increases the availability of dopamine and serotonin, both crucial for emotional regulation, motivation, and executive function. It has been shown to enhance memory, neuroplasticity, and cognitive performance in multiple studies.

BDNF Upregulation: Selank has been found to rapidly elevate the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, supporting neuroplasticity, learning, and memory formation.

Immunomodulatory Effects: As an analog of tuftsin, Selank modulates the expression of Interleukin-6 (IL-6) and affects the balance of T helper cell cytokines, providing immune system support alongside its neurological benefits.

Potential Mechanism of Action: Selank works through multiple pathways:

1. Enhances GABAergic neurotransmission without benzodiazepine side effects

2. Modulates dopamine and serotonin systems for mood and cognition

3. Increases BDNF expression for neuroplasticity and learning

4. Regulates cytokine expression for immune support

5. Inhibits enzymes that degrade enkephalins and regulatory peptides

6. Normalizes sleep-wake balance without sedation

SELANK LIFESTYLE SUPPORT

LIFESTYLE SUPPORT: 

• Quality sleep (7-9 hours) for optimal neurological function 

• Stress management techniques (meditation, breathing exercises) 

• Regular physical activity to enhance neuroplasticity 

• Balanced diet rich in omega-3 fatty acids and antioxidants 

• Mental stimulation through learning and challenging activities 

• Social engagement and meaningful relationships

WHAT TO EXPECT:

IMPORTANT: Effects vary - some experience rapid response, others gradual improvement!

• 40% of users may experience rapid anxiety relief within 1-3 days 

• 60% of users experience gradual improvement over 2 weeks 

• Enhanced focus and mental clarity often noticed within days 

• Improved mood and stress resilience builds over weeks 

• Cognitive benefits accumulate with consistent use 

• No sedation or "drugged" feeling unlike benzodiazepines

SELANK DOSING + CYCLING

Standard Intranasal Protocol: 300mcg 2-3x daily

Selank	Preparation	Strength	Dose	Frequency	Supply
10 mg Vial	10 mL sterile water/saline	1mg/mL	300mcg (3 drops per nostril)	2-3x daily	11-16 days

Cycling: 2-4 weeks on, 1-2 weeks off, repeat as needed

• Intranasal administration preferred for rapid absorption 

• 1-2 drops per nostril, 2-3 times daily 

• Morning and midday doses most common 

• Avoid evening dosing if it interferes with sleep

SELANK DOSING + CYCLING

Injectable Protocol: 250-500mcg daily

Selank	Bacteriostatic water added	Strength mg/mL	Dose	Frequency	Supply
10 mg Vial	2 mL	5mg/mL	250-500mcg (5-10 units)	Daily	20-40 days

Cycling: 3-4 weeks on, 1-2 weeks off, repeat cycles as needed

• Subcutaneous injection (abdomen, thigh, arm) 

• Once daily administration typical 

• Morning or early afternoon preferred 

• Effects build over several days to weeks

SELANK: SCREENING

Selank is generally well-tolerated with minimal contraindications.

Screening Questions: • Do you have any active cancer or tumor history? • Are you pregnant or breastfeeding? • Do you have severe psychiatric disorders or psychosis? • Are you taking benzodiazepines or other GABAergic medications?

Reasons: • Caution advised with active malignancies due to immune modulation • Insufficient safety data during pregnancy/breastfeeding • May interact with other GABAergic medications • Should be used under medical guidance for severe psychiatric conditions

Note: Selank has a favorable side effect profile compared to benzodiazepines with no documented dependence potential, tolerance development, or withdrawal symptoms. The peptide is metabolized rapidly and eliminated within minutes, but effects last hours to days.